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A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes. For this reason, growth factors are important in a number of cell based assay, therapeutic, clinical, diagnostic, and drug design applications.
In cell culture including stem cell, the growth factors used to supplement media are frequently derived from animal blood, such as calf serum. One complication of these blood-derived ingredients is the potential for contamination of the culture with viruses or prions, particularly in biotechnology medical applications. Current approach is to minimize or eliminate the use of these ingredients wherever possible, but this cannot always be accomplished.
It would be advantageous to incorporate peptides mimicking the biological activity of the large, natural growth factors.
Small peptide mimics of natural growth factors can be easily incorporated into a mussel adhesive protein with comparable biological activity. We provide mussel adhesive protein based growth factor mimetic, functionalized with scientifically and/or clinically proven peptide.
Contact us for detailed MAPTrixTM based growth factor mimetic products.
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| Transforming Growth Factor beta
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| Mussel adhesive protein containing TGF derived peptide can facilitate and promote angiogenesis in development, inflammation, or wound healing. Currently our TGF derived peptide line of products include the HADLLAVVAASQ (TGF-α) and KVLALYNK (TGF-β) motifs. We plan to extend this product line to recombinant mussel adhesive proteins for use in cell culture & therapy, and tissue engineering applications. In primary human umbilical vein endothelial cells (HUVECs) cultured with MAPTrixTM-TGF, HUVECs formed the capillary tube, indicating that MAPTrixTM-TGF mimics might play a role of angiogenesis in development, inflammation, or wound healing. |
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| Fibroblast Growth Factor
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| Fibroblast growth factors, or FGFs (aFGF and bFGF), are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. Fibroblast Growth Factor-basic (bFGF, FGF-2) is a heparin binding growth factor which stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal, endothelial, and human embryonic stem cells. bFGF also exerts a potent angiogenic activity in vivo. Fibroblast Growth Factor-acidic (FGF-a or FGF-1) is a heparin binding growth factor which stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal andendothelial cells. Currently our FGF derived peptide line of products include the FNLPLGNYKKP (aFGF) and ERGVVSIKGV (bFGF) motifs. |
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| Nerve Growth Facotr
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| Nerve growth factor (NGF) and other growth factors act via cell surface receptors to prevent neuronal death in the contexts of neural development, neurodegenerative disease, ischemia, axotomy and excessive excitatory amino acids. They also promote neural regeneration and enhance neuronal function. Many studies have indicated the hydrophilic loops 1 and 4 and the N-terminal region of NGF as the most relevant for its biological activity. Currently our NGF derived peptide line of products include PEAHWTKLQHSLDTALR motif. |
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| Insulin-like Growth Factor |
Insulin-like growth factors or IGFs (IGF I and II) are peptide hormones secreted from many different cells. IGF I,also known as somatomedin C, and II play a role in uterine and placental growth and early fetal growth during pregnancy. IGF-I is a peptide hormone which is mainly produced in the liver in the presence of growth hormone1 and released into the blood. It is a potent mitogenic growth factor that mediates the growth-promoting activities of growth hormone postnatally. Currently our IGF derived peptide line of products include the GYGSSSRRAPQT(IGF I) and SRVSRRSR (IGF II) motifs.
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